How to use Silkis ointment

Silkis ointment is for use on the skin only. You should use this treatment exactly as instructed by your doctor or pharmacist.

To apply Silkis ointment:

• First, wash and dry the affected areas of skin.
• Apply a thin layer of the ointment to the affected areas (apply especially carefully to the face, as there is a greater risk of irritation).
• Repeat this twice a day, once in the morning and once before you go to bed (or as advised by your doctor or pharmacist).
• Wash your hands thoroughly after each application.
• You should use no more than 30g of the ointment each day, and cover no more than a third of your total skin area (approximately one full arm and one full leg).

If you use more Silkis ointment than you should:

• You will not achieve better or faster results, but redness, peeling or discomfort may occur.
• Hypotonia (decreased muscle tension), nausea, vomiting, lack of appetite, constipation, and depression may also occur if you use too much Silkis.
• Contact your doctor or pharmacist, particularly if you experience any of the above side effects of using too much Silkis ointment.

If you forget to apply Silkis, do not apply double the amount to make up for it. Simply apply Silkis as normal the next time.

Silkis ointment ingredients

The active ingredient in Silkis is calcitriol (3 micrograms per g).

The other ingredients are liquid paraffin, white soft paraffin, and alpha-tocopherol.

Sources

Silkis Patient Information Leaflet: https://www.medicines.org.uk/emc/files/pil.1602.pdf

Silkis ointment side effects

As with all medicines, it’s possible that you may experience side effects when using Silkis ointment, though not everyone will be affected.

Common side effects (affecting up to 1 in 10 people) include:

• Pruritus (itching skin)
• Skin discomfort
• Skin irritation
• Erythema (skin redness)

Less common side effects (affecting up to 1 in 100 people) include:

• Dry skin
• Aggravation of psoriasis symptoms

Skin oedema (fluid retention) and contact dermatitis are also possible side effects, though these are thought to be very rare (their frequency cannot be estimated from the available data).

In the case of severe irritation or an allergic reaction, you should stop using the treatment immediately and seek medical attention.

If you experience any side effects, including any that are not listed above, contact your doctor or pharmacist for advice.

Silkis ointment warnings

Before using Silkis ointment to treat psoriasis, you should be aware of the following warnings and precautions:

• When using Silkis ointment on the face, be sure to apply it carefully since there is a greater risk of irritation.
• After applying the ointment, wash your hands thoroughly to prevent unintentional spread to non-affected areas.
• Do not swallow this product. If you accidentally do so, rinse your mouth with water and seek medical advice as quickly as possible.
• Do not smoke or go near naked flames when you have applied the ointment, as there is a risk of severe burns. Note that fabric (clothing, bedding etc.) that has been in contact with the ointment may become more flammable.
• Due to a potential effect on calcium metabolism, Silkis should not be applied under an occlusive wound dressing.
• Although no significant hypercalcaemia (high blood calcium) was observed during clinical studies, there is some absorption of calcitriol by the skin which means there is a risk of an increase of blood or urine calcium levels. You can reduce this risk by following the advice of your doctor or pharmacist.

You should not use Silkis ointment if any of the following apply to you:

• You have a kidney or liver disease.
• You are being treated by systemic (oral) route for a calcium deficiency.
• You have high blood calcium levels (hypercalcaemia) or you suffer from abnormal calcium metabolism.
• You are allergic to calcitriol or to any of the other ingredients listed below.

Can you use Silkis with other medications?

You should inform your doctor or pharmacist if you are taking, have recently taken, or are planning to take any other medications alongside Silkis, including other topical medications you are using or have previously used to treat psoriasis.

Silkis might interfere with other medicines such as:

• Thiazide diuretics, as this could lead to an increase in blood calcium levels when taken alongside this medicine.
• Medications whose actions can be modified by a change in calcium blood level, such as digoxin.
• Peeling agents, irritant agents, or astringent agents, as additional irritant effects might occur.
• Calcium supplements or high doses of vitamin D.

Can you use Silkis while pregnant or breastfeeding?

If you are pregnant, think you may be pregnant, or are planning to have a baby in the near future, consult your doctor or pharmacist before taking this medicine. Silkis should not be used if you are breastfeeding.

Can Silkis be used on children?

Since there is limited data on the use of Silkis in children, this treatment is not recommended for use by those under the age of 16.