Syndol tablets provide pain relief from causes such as headache, migraine, toothache, muscle pain and period pain. It is an over-the-counter alternative for cases in which aspirin, paracetamol or ibuprofen have been ineffective.

Syndol does not require a prescription. However, take care to always read the label.

The active ingredient in Benadryl one A Day tablets is a non-sedating antihistamine called cetirizine. Allergy symptoms occur due to the activity of mast cells. These cells are responsible for the immune system’s reaction to foreign particles. When an allergen enters the body, mast cells release substances such as histamine. This binds to H1 receptors, which causes an inflammatory response, leading to congestion and watery eyes.

Antihistamines work in different ways. Whereas some other medicines inhibit the release of histamine, cetirizine prevents histamine from reaching its H1 receptors. This blocks the body’s inflammatory response to allergens, easing the frustrating symptoms of hayfever and other allergies.

In recent years Syndol has been reformulated. Its current formulation contains paracetamol (500mg), codeine (8mg) and caffeine (30mg). It no longer contains an ingredient called doxylamine, which is an antihistamine

Syndol is manufactured by Sanofi. Sanofi have been working with both the manufacturing plants and regulatory authorities to determine whether the original Syndol formulation can be brought back. Whether this will happen cannot be confirmed, but we will keep you updated as to any decisions made.

Doxylamine is a non-habit forming antihistamine. It works by blocking the production of histamine and acetylcholine in the body. This action can cause drowsiness, which can help aid sleep. The current formulation of Syndol, which has been approved by the regulatory authorities, does not contain doxylamine. This means the product causes less drowsiness.

Anugesic HC Cream should be applied twice each day, and after each bowel movement.

Before use, wash your hands and the affected area thoroughly with water. Gently dry the skin around the anus to prevent further irritation.

For internal use, a nozzle is provided, which screws on to the top of the tube. Gently insert the tip of the nozzle into the anus, and squeeze the tube such that a small amount of cream is released. Withdraw the nozzle carefully, then use warm water to thoroughly wash both the nozzle and your hands.

Anugesic HC suppositories should be inserted into the rectum.

Syndol is unsuitable for the following types of people:

• Those with respiratory problems (e.g. shallow breathing, asthma, chronic obstructive pulmonary disease
• Those with an allergy to any of this medicine’s ingredients
• Those at risk of paralytic ileus (an intestinal blockage caused by nerve or muscle problems)
• Those with increased pressure within the skull
• Those with a liver enzyme CYP3D6 which converts codeine into morphine – this will increase the risk of side effects
• Women who are pregnant or breastfeed
• Anyone under the influence of alcohol
• Children under the age of 12
• Adolescents (under the age of 18) who have had their tonsils removed
• Adolescents (under the age of 18) with breathing problems or heart conditions

Although each tablet contains only a small amount of codeine, it may still cause drowsiness. Do not drive or operate machinery until you know that Syndol will not make you feel tired or dizzy. The liver converts codeine into morphine – it is illegal to drive if this medicine is present in your saliva.

Side effects of this medicine can vary significantly depending on how your body breaks down codeine. The range of possible side effects includes drowsiness, dizziness, shallow breathing, reduced appetite, constipation, nausea and small pupils.

Syndol contains a small amount of caffeine. Take care if also consuming caffeine from other sources, as this may lead to unwanted side effects including anxiety, irritability, insomnia or further headaches.

Avoid other medicines containing paracetamol while using Syndol.

Do not exceed the recommended dose of Syndol, as it may be harmful to the kidneys and/or liver. Seek medical attention if you substantially exceed the recommended dose.

Avoid drinking alcohol while using Syndol, as it may increase your chance of an overdose of paracetamol.

Syndol is only suitable for adults and children over the age of 12 years. It should not be taken by children under 12. Always read the product packaging and patient information leaflet prior to use.

Syndol Headache relief Tablets are only for short-term use (up to 3 days). They are suitable for treating acute moderate pain that is not sufficiently relieved by paracetamol, ibuprofen or aspirin alone. Syndol can effectively provide relief from; headaches, migraines and other pain.

You should take 2 tablets every 4 hours when required. Never take more than 8 tablets in a 24 hour period. Syndol should only be taken for a maximum of 3 days. If you need to it for longer than 3 days, see your doctor or pharmacist for advice. Taking painkillers for headaches for longer than three days can actually make them worse.

Syndol should not be taken at the same time as other products containing paracetamol. Always read the patient information leaflet for further contraindications.

No, Syndol Headache Relief Tablets can be purchased over-the-counter without a prescription.